SidaGhanaV1, Main, Exploration, bibRecord, 001148

Haptoglobin Polymorphism in Human Immunodeficiency Virus Infection: Hp0 Phenotype Limits Depletion of CD4 Cell Counts in HIV-1—Seropositive Individuals

Identifieur interne : 001148 ( Main/Exploration ); précédent : 001147; suivant : 001149

Haptoglobin Polymorphism in Human Immunodeficiency Virus Infection: Hp0 Phenotype Limits Depletion of CD4 Cell Counts in HIV-1—Seropositive Individuals

Auteurs : Isaac K. E. Quaye [Niger] ; Jim Brandful ; Fred A. Ekuban ; Ben Gyan [Ghana] ; Nii-Ayi Ankrah

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2000-04.

RBID : ISTEX:E3F715617531AA601272E8758C812183491F25CC

Descripteurs français

KwdFr :
- Adulte, Allèles, Femelle, Haptoglobines (génétique), Humains, Infections à VIH (génétique), Infections à VIH (immunologie), Mâle, Numération des lymphocytes CD4, Phénotype, Polymorphisme génétique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
MESH :
- génétique : Haptoglobines, Infections à VIH.
- immunologie : Infections à VIH.
- Adulte, Allèles, Femelle, Humains, Mâle, Numération des lymphocytes CD4, Phénotype, Polymorphisme génétique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).

English descriptors

KwdEn :
- Adult, Alleles, CD4 Lymphocyte Count, Female, HIV Infections (genetics), HIV Infections (immunology), HIV-1, Haptoglobins (genetics), Humans, Male, Phenotype, Polymorphism, Genetic.
MESH :
- chemical , genetics : Haptoglobins.
- genetics : HIV Infections.
- immunology : HIV Infections.
- Adult, Alleles, CD4 Lymphocyte Count, Female, HIV-1, Humans, Male, Phenotype, Polymorphism, Genetic.

Abstract

Patients seropositive for human immunodeficiency virus (HIV) type 1 and seronegative control subjects were categorized by their haptoglobin phenotypes, which were determined by electrophoresis of hemoglobin-supplemented plasma samples followed by benzidine staining. The CD4 cell counts, determined by flow cytometry from peripheral blood mononuclear cells according to subject categories, were severely diminished in seropositive patients with the Hp2-2 phenotype (P<.025). In contrast, the CD4 cell counts for patients with the Hp0 phenotype remained relatively high (P<.025), compared with those of the controls. In seronegative patients, CD4 cell counts were generally high (P<.005), but they were more elevated in subjects with Hp2-2 and Hp1-1, although the differences were not significant. Thus, the Hp2-2 phenotype is associated with poor outcome in HIV-1 infection, whereas the Hp0 phenotype is associated with a better prognosis once the patient is infected with HIV-1. Haptoglobin polymorphism plays a significant role in HIV-1 infection and transmission.

Url:

https://api.istex.fr/document/E3F715617531AA601272E8758C812183491F25CC/fulltext/pdf

DOI: 10.1086/315377

Affiliations:

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<front><div type="abstract">Patients seropositive for human immunodeficiency virus (HIV) type 1 and seronegative control subjects were categorized by their haptoglobin phenotypes, which were determined by electrophoresis of hemoglobin-supplemented plasma samples followed by benzidine staining. The CD4 cell counts, determined by flow cytometry from peripheral blood mononuclear cells according to subject categories, were severely diminished in seropositive patients with the Hp2-2 phenotype (P<.025). In contrast, the CD4 cell counts for patients with the Hp0 phenotype remained relatively high (P<.025), compared with those of the controls. In seronegative patients, CD4 cell counts were generally high (P<.005), but they were more elevated in subjects with Hp2-2 and Hp1-1, although the differences were not significant. Thus, the Hp2-2 phenotype is associated with poor outcome in HIV-1 infection, whereas the Hp0 phenotype is associated with a better prognosis once the patient is infected with HIV-1. Haptoglobin polymorphism plays a significant role in HIV-1 infection and transmission.</div>
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Le SIDA au Ghana (serveur d'exploration)

Haptoglobin Polymorphism in Human Immunodeficiency Virus Infection: Hp0 Phenotype Limits Depletion of CD4 Cell Counts in HIV-1—Seropositive Individuals

Haptoglobin Polymorphism in Human Immunodeficiency Virus Infection: Hp0 Phenotype Limits Depletion of CD4 Cell Counts in HIV-1—Seropositive Individuals

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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